Cardiovascular abnormalities that induce heart failure with preserved ejection fraction(HFpEF) eventually increases left ventricular(LV) myocardial stiffness(MS). Currently, MS is measured using LV catheterization. However, this procedure is invasive and only gives global measurements. Previous study has shown feasibility of cardiac Magnetic Resonance Elastography(MRE) in determining MS and validated against LV catheterization. Histopathology of ex-vivo samples can provide fibrosis content. Aim of this study is to estimate MS using cardiac MRE in HFpEF porcine model and validate against histopathology results. Preliminary study demonstrate increased LV stiffness correlates well with increase in fibrosis from histopathology in diseased samples when compared to healthy.
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