Accelerating Quantitative Chemical Exchange Saturation Transfer MRI using MR Fingerprinting and Synthetic CEST Analysis
Hye Young Heo1,2, Zheng Han1,2, Shanshan Jiang1, Michael Schar1, Peter C.M. van Zijl1,2, and Jinyuan Zhou1,2
1Radiology, Johns Hopkins University, Baltimore, MD, United States, 2Kennedy Krieger Institute, Baltimore, MD, United States
Current CEST-MRI approaches are qualitative in nature, producing contrast that has dependency on both exchange rate and the concentration of the exchangeable protons in metabolites. This limits pH or metabolite concentration specificity unless one of these two parameters can be varied individually in an experiment. Here, we developed a fast CEST imaging technique based on MR fingerprinting approach that can achieve such quantification using a saturation time and strength varied RF scheme. The approach is validated using simulations and ammonium chloride phantoms, and then demonstrated in-vivo for amide proton transfer (APT) MRI.
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