Abstract #1154

Rapid and Accurate CEST and NOE MRI of Injured Spinal Cord Using Multi-Pool Fitting

Feng Wang^1,2, Zhong-Liang Zu^1,2, Tung-Lin Wu^1,3, Xinqiang Yan^1,2, John C. Gore^1,2,3, and Li Min Chen^1,2

¹Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, ²Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ³Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

This study aims to evaluate the accuracy of estimates of the amplitudes of specific CEST and NOE effects in Z-spectra derived from multi-pool fitting using down sampled data, and their sensitivity for assessing injury-associated changes in spinal cords of squirrel monkeys. An inverse subtraction analysis corrected for changes in the apparent water longitudinal relaxation rate R_1obs (AREX_mfit) was used to quantify regional spectra around lesion sites. The results provide an optimized rapid, sensitive, and accurate protocol for deriving both NOE and CEST effects in spinal cord imaging at high field.

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