Abstract #1162

In Vivo Multicomponent 3D-T1ρ Relaxation Mapping of Human Liver under Free-breathing

Azadeh Sharafi¹, Rahman Baboli¹, Krishna Shanbhogue¹, Sonja Olsen², Tobias Block¹, Hersh Chandarana¹, and Ravinder Regatte¹

¹Radiology, NYU Langone Health, New York, NY, United States, ²Medicine, NYU Langone Health, New York, NY, United States

Chronic hepatic disease damages the liver and the subsequent wound-healing process results in liver fibrosis which can ultimately progress to cirrhosis. In this study, we evaluated bi-exponential 3D-T_1ρ mapping for in-vivo liver applications under free breathing on a standard clinical 3T scanner, employing combinations of golden-angle radial sampling and parallel imaging. The proposed free-breathing multi-component 3D-T_1ρ mapping technique has potential for assessment of liver inflammation and fibrosis, and it could serve as future imaging biomarker for disease-modifying liver-fibrosis therapies.

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