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Abstract #1162

In Vivo Multicomponent 3D-T1ρ Relaxation Mapping of Human Liver under Free-breathing

Azadeh Sharafi1, Rahman Baboli1, Krishna Shanbhogue1, Sonja Olsen2, Tobias Block1, Hersh Chandarana1, and Ravinder Regatte1

1Radiology, NYU Langone Health, New York, NY, United States, 2Medicine, NYU Langone Health, New York, NY, United States

Chronic hepatic disease damages the liver and the subsequent wound-healing process results in liver fibrosis which can ultimately progress to cirrhosis. In this study, we evaluated bi-exponential 3D-T mapping for in-vivo liver applications under free breathing on a standard clinical 3T scanner, employing combinations of golden-angle radial sampling and parallel imaging. The proposed free-breathing multi-component 3D-T mapping technique has potential for assessment of liver inflammation and fibrosis, and it could serve as future imaging biomarker for disease-modifying liver-fibrosis therapies.

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