Abstract #1182

Rapid, Time-Resolved Brain Imaging with Multiple Clinical Contrasts using Wave-Shuffling.

Siddharth Srinivasan Iyer^1,2, Daniel Polak^1,3,4, Congyu Liao¹, Steve Cauley¹, Berkin Bilgic¹, and Kawin Setsompop¹

¹Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, ²Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, ³Department of Physics and Astronomy, Heidelberg University, Heidelberg, Germany, ⁴Siemens Healthcare GmbH, Erlangen, Germany

Previously, we presented Wave-Shuffling: a technique that combines random-sampling and the temporal low-rank priors of T₂-shuffling with the sinusoidal gradients of Wave-CAIPI to achieve highly-accelerated, time-resolved acquisitions. In this work, we optimize and apply Wave-Shuffling to T₂-SPACE and MPRAGE to achieve rapid, 1 mm-isotropic resolution, time-resolved imaging of the brain where we recover a time-series of clinical contrast. We also present preliminary explorations into Joint-Contrast Wave-Shuffling to boost signal-to-noise ratio and reconstruction-conditioning at high accelerations.

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