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Abstract #1189

Combined T1, T2, and T2* mapping using a multi-inversion multi-echo spin and gradient echo EPI sequence

Mary Kate Manhard1,2, Congyu Liao1,2, Jason Stockmann1,2, Daniel Park1, SoHyun Han1,2, Jonathan R. Polimeni1,2,3, Berkin Bilgic1,2, and Kawin Setsompop1,2,3

1A.A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2Department of Radiology, Harvard Medical School, Boston, MA, United States, 3Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, United States

Rapid EPI acquisitions are limited by geometric distortion and blurring due to long readouts. Here we incorporate several recent advances in reconstruction approaches and hardware technology to mitigate some of these errors, and implement a multi-echo multi-inversion EPI-based sequence that can be used to find quantitative proton density, T1, T2, and T2* maps. In addition, high quality clinical contrasts can be generated from these maps including T2-, T2*-, T1-, and FLAIR-weighted images. Our protocol provides high-quality, whole-brain, multi-contrast maps with minimal distortion in scan times of 1-3 minutes.

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