Abstract #1214

Image contrast at 0.55T

Adrienne E Campbell-Washburn¹, Daniel A Herzka¹, Peter Kellman², Alan P Koretsky³, and Robert S Balaban²

¹Cardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States, ²Systems Biology Center, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States, ³Laboratory of Functional Molecular Imaging, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States

In addition to having cost advantages, low-field MRI may offer new imaging opportunities by virtue of the physical attributes. Here we report T1, T2 and T2* tissue parameters and contrast agent relaxivities for a custom high performance 0.55T MRI system. We found that T1 was 29% shorter at 0.55T compared 1.5T, whereas T2 was lengthened by 33% and T2* was lengthened by 54% at 0.55T. Marketed small molecular weight gadolinium-based contrast agents demonstrate similar relaxivity at 0.55T and 1.5T, indicating similar dosing requirements, and larger molecular complex agents had increased T1 relaxivity at 0.55T, indicating potential advantages at low-field.

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