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Abstract #1216

Free Breathing R2* Mapping Using Three-Dimensional Self-Gating Motion-Compensated Stack-of-Radial MRI

Xiaodong Zhong1, Tess Armstrong2,3, Marcel Dominik Nickel4, Stephan A.R. Kannengiesser4, Li Pan5, Vibhas Deshpande6, and Holden H Wu2,3

1MR R&D Collaborations, Siemens Healthineers, Los Angeles, CA, United States, 2Department of Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, 3Department of Physics and Biology in Medicine, University of California Los Angeles, Los Angeles, CA, United States, 4MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany, 5MR R&D Collaborations, Siemens Healthineers, Baltimore, MD, United States, 6MR R&D Collaborations, Siemens Healthineers, Austin, TX, United States

R2* mapping is an emerging biomarker to evaluate iron overload. Due to its relative insensitivity to motion, free-breathing 3D stack-of-radial imaging is a useful technique in patient populations with breath-hold difficulties. However, its performance for R2* quantification is still under investigation. This study proposes a new 3D self-gating motion-compensated free-breathing stack-of-radial MRI method for R2* quantification. Preliminary in vivo results demonstrated good agreement of R2* mapping in the liver with the proposed method compared to the reference results of breath-hold Cartesian MRI.

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