Abstract #1216

Free Breathing R2* Mapping Using Three-Dimensional Self-Gating Motion-Compensated Stack-of-Radial MRI

Xiaodong Zhong¹, Tess Armstrong^2,3, Marcel Dominik Nickel⁴, Stephan A.R. Kannengiesser⁴, Li Pan⁵, Vibhas Deshpande⁶, and Holden H Wu^2,3

¹MR R&D Collaborations, Siemens Healthineers, Los Angeles, CA, United States, ²Department of Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, ³Department of Physics and Biology in Medicine, University of California Los Angeles, Los Angeles, CA, United States, ⁴MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany, ⁵MR R&D Collaborations, Siemens Healthineers, Baltimore, MD, United States, ⁶MR R&D Collaborations, Siemens Healthineers, Austin, TX, United States

R2* mapping is an emerging biomarker to evaluate iron overload. Due to its relative insensitivity to motion, free-breathing 3D stack-of-radial imaging is a useful technique in patient populations with breath-hold difficulties. However, its performance for R2* quantification is still under investigation. This study proposes a new 3D self-gating motion-compensated free-breathing stack-of-radial MRI method for R2* quantification. Preliminary in vivo results demonstrated good agreement of R2* mapping in the liver with the proposed method compared to the reference results of breath-hold Cartesian MRI.

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