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Abstract #1227

Multi-Parametric MRI of Liver Fibrosis and Treatment Response in a Rat Model of Nonalcoholic Steatohepatitis (NASH)

Iris Y. Zhou1, Veronica Clavijo Jordan1, Nicholas Rotile1, Smitha Krishnan2, Hema Krishnan1, Gunisha Arora2, Hannah Slattery1, Noah Warner1, Christian T. Farrar1, Bryan C. Fuchs2, and Peter Caravan1

1Athinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging (i3), Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, 2Division of Surgical Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States

Noninvasive MR quantification of matrix using a collagen-binding molecular MR probe and tissue stiffness by MR elastography were used to assess liver fibrosis and the anti-fibrotic effects of elafibranor or diet change in a rat model of nonalcoholic steatohepatitis (NASH). Reduction of fibrosis after diet change or elafibranor treatment were detected by EP-3533 collagen imaging and stiffness measurements and correlated with morphometric assessment of fibrosis from histology and with hydroxyproline content as a biochemical surrogate for total liver collagen. Multi-parametric MRI can be used to characterize disease progression and serve as sensitive tool for evaluating treatment response.

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