Abstract #1233

Improving the accuracy of Blood Oxygen Level Dependent Imaging using FLASH normalised T2 prepared SSFP acquisition

Betty Raman¹, Kenneth Chan ¹, Rina Ariga ¹, Moritz Hundertmark¹, Masliza Mahmod ¹, Stefan Neubauer ¹, Aaron Hess¹, and Elizabeth Tunnicliffe ¹

¹Radcliffe Department of Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxfordshire, United Kingdom

T2-prepared steady state free precession (SSFP) Blood Oxygen Level Dependent (BOLD) imaging is a promising technique for ischaemia detection but has wide normal ranges, in part because the signal intensity is heart-rate dependent. Fast low angle shot (FLASH) readouts can be interleaved with the SSFP readouts to normalise SSFP images, rendering it heart-rate insensitive. In this study, we examined the variability and reproducibility of standard and FLASH-normalised T2-prepared SSFP BOLD in healthy subjects. FLASH-normalised T2-prepared SSFP BOLD produced a highly reproducible normal BOLD range with an effect size similar to that of the standard method and with considerably reduced variability.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.