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Abstract #1282

Mapping of myoglobin oxygen saturation dynamics in the calf during ischemia with a modified slab-selective 2D NMRSI pulse sequence at 3T.

Alfredo Liubomor Lopez Kolkovsky1,2, Martin Meyerspeer3,4, and Pierre G Carlier1,5

1NMR Laboratory, Institute of Myology, Paris, France, 2NMR Laboratory, CEA / DRF / IBFJ/ MIRCen, Paris, France, 3Division MR Physics, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria, 4High Field MR Center, Medical University of Vienna, Vienna, Austria, 5NMR Laboratory, CEA / DRF / IBFJ / MIRCen, Paris, France

Myoglobin in its deoxygenated form is a 1H NMR visible biomarker of intracellular oxygenation. Its low concentration and very short relaxation times have been major challenges to map deoxy-myoglobin dynamically during a transient state, such as ischemia. Here, we interleaved the acquisition of a full 2D CSI data set at the dMb frequency (~79 ppm), a non-localized dMb spectrum and an anatomical image with radial encoding to track dMb dynamics during an ischemic bout with a temporal resolution of 3.5 seconds. Promising proof-of-concept results are shown. This method suggests a strong potential for energy metabolism studies in vivo.

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