Osteoarthritis (OA) is a degenerative joint disease that commonly affects bilateral joints. This study combined simultaneous bilateral knee MRI with an automatic image processing for faster acquisition to image biomarker extraction. Simultaneous bilateral knee MRIs of 5 healthy volunteers was compared to singularly acquired knee images. Isotropic 3D CUBE FSE were used to automatically segment cartilage. Voxel based relaxometry from 3D combined T1ρ/T2 was evaluated for both types of acquisition. Our results show the ability of dual coil configuration allows for high resolution isotropic images, while also retaining the accuracy of quantitative data when compared to singly acquired bilateral knees.