Abstract #1327

Localization of the bright ultra-short echo time MRI signal at the osteochondral interface

Olli Juhani Nykänen¹, Henri Leskinen¹, Mikko Finnilä^1,2, Sakari Karhula², Simo Saarakkala^2,3, and Mikko J Nissi^1,2

¹Department of Applied Physics, University of Eastern Finland, Kuopio, Finland, ²Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, ³Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland

In this study, we investigated the bright signal feature that has been observed at the bone-cartilage interface using ultrashort echo time imaging sequences. We used micro-CT imaging of the same specimens to locate the origin of the signal in SWIFT-MRI images. The results indicated that the bright signal originates from the deep non-calcified cartilage region instead of the calcified cartilage, which has been previously hypothesized to be part of the signal location. The physiological origin of this signal as well as its role in the diagnosis of osteoarthritis remains to be evaluated.

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