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Abstract #1336

Longitudinal Analysis of Spontaneous Mechanical Activities in Resting Leg Musculature Assessed by Diffusion-Weighted Imaging: Preliminary Results

Martin Schwartz1,2, Günter Steidle1, Petros Martirosian1, Thomas Küstner1,2,3, Jürgen Machann1,4,5, Anja Böhm4,5,6, Cora Weigert4,5,6, Bin Yang2, and Fritz Schick1

1Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Hospital of Tübingen, Tübingen, Germany, 2Institute of Signal Processing and System Theory, University of Stuttgart, Stuttgart, Germany, 3School of Biomedical Engineering & Imaging Sciences, King’s College London, St. Thomas’ Hospital, London, United Kingdom, 4Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany, 5German Center for Diabetes Research (DZD), Tübingen, Germany, 6Department of Endocrinology and Diabetology, Angiology, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany

Accurate quantification and grading of spontaneous mechanical activity of musculature of healthy and non-healthy subjects as measurable by single-shot diffusion-sensitive MRI requires certain long-term stability in order to reflect changes in the underlying muscular condition. Up to now, no longitudinal studies have been conducted, thus short- as well as long-term variation in the same subject under examination is unknown. This work examines the impact of the time of day when the examination takes places as well as long-term changes over 23-62 months in several subjects.

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