Abstract #1336

Longitudinal Analysis of Spontaneous Mechanical Activities in Resting Leg Musculature Assessed by Diffusion-Weighted Imaging: Preliminary Results

Martin Schwartz^1,2, Günter Steidle¹, Petros Martirosian¹, Thomas Küstner^1,2,3, Jürgen Machann^1,4,5, Anja Böhm^4,5,6, Cora Weigert^4,5,6, Bin Yang², and Fritz Schick¹

¹Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Hospital of Tübingen, Tübingen, Germany, ²Institute of Signal Processing and System Theory, University of Stuttgart, Stuttgart, Germany, ³School of Biomedical Engineering & Imaging Sciences, King’s College London, St. Thomas’ Hospital, London, United Kingdom, ⁴Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany, ⁵German Center for Diabetes Research (DZD), Tübingen, Germany, ⁶Department of Endocrinology and Diabetology, Angiology, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany

Accurate quantification and grading of spontaneous mechanical activity of musculature of healthy and non-healthy subjects as measurable by single-shot diffusion-sensitive MRI requires certain long-term stability in order to reflect changes in the underlying muscular condition. Up to now, no longitudinal studies have been conducted, thus short- as well as long-term variation in the same subject under examination is unknown. This work examines the impact of the time of day when the examination takes places as well as long-term changes over 23-62 months in several subjects.

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