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Abstract #1349

T2, MTR, and diffusion tensor quantitative MRI methods reliably monitor AAV-mediated gene therapy treatment in a murine muscular dystrophy model

Yasser Nazari1, Joshua Park1, Guy Odom2, Ravneet Vohra1, Jeff Chamberlain2, and Donghoon Lee1

1Department of Radiology, University of Washington, Seattle, WA, United States, 2Department of Neurology, University of Washington, Seattle, WA, United States

Herein we investigate the capability of multi-parametric MRI to reliably and decisively monitor both minute qualitative and quantitative changes in the skeletal muscle microenvironment in a Duchenne muscular dystrophy mouse model, namely mdx4Cv. Through the use of an assortment of pulse sequences, including T2, magnetization transfer ratio, and diffusion tensor imaging, the progression of a recombinant adeno-associated viral vector treatment, by the delivery of a truncated micro-dystrophin gene, is monitored in these mice and better understood. This study fundamentally seeks to understand and confirm the practicality of MRI as a diagnostic and prognostic measure in muscular dystrophy models.

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