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Abstract #1370

Bone Fraction Mapping with SyNthetic Auto-interpolated in-Phase (SNAP) MRI

Naomi Sakai1, Timothy Bray1, Stuart Taylor1, Margaret Hall-Craggs1, and Alan Bainbridge2

1UCL Centre for Medical Imaging, University College London, London, United Kingdom, 2Department of Medical Physics, University College London Hospitals, London, United Kingdom

Quantification of bone mineral density (BMD) and/or bone fraction (BF) has long been a goal of MRI research, but thus far no method has successfully translated into clinical practice. Methods including R2* mapping, susceptibility mapping and ultrashort echo time MRI have shown promise but remain difficult to implement. A simpler approach to BMD/BF quantification is to measure the signal loss occurring in bone-containing voxels compared to the signal occurring in a bone-free voxel. We propose a method called SyNthetic Auto-interpolated in-Phase (SNAP) imaging which uses this principle and accounts for spatial variations in B1/coil sensitivity, enabling practical estimation of BMD/BF.

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