Abstract #1379

Exploratory evaluation of magnetic resonance fingerprinting confirms increased T1 and T2 in metastatic breast and prostate cancer lesions compared with normal marrow and volunteer values

Matthew R Orton¹, Mihaela Rata^1,2, Nina Tunariu^1,2, Julie Hughes², Erica Scurr², James A d'Arcy¹, Martin O Leach¹, Wei-Ching Lo³, Mark Griswold^3,4, Yun Jiang³, Vikas Gulani^3,4, and Dow-Mu Koh^1,2

¹CRUK Cancer Imaging Centre, Division of Radiotherapy and Imaging, Institute of Cancer Research, London, United Kingdom, ²Department of Radiology, Royal Marsden NHS Foundation Trust, London, United Kingdom, ³Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ⁴Department of Radiology, Case Western Reserve University, Cleveland, OH, United States

Magnetic resonance fingerprinting (MRF) is a rapid imaging technique that allows generation of multiple, co-registered quantitative maps from a single sequence. This technique has been evaluated in the brain, abdomen, prostate, breast and heart, but has not been applied to metastatic disease in the skeleton. This abstract documents T1 and T2 values obtained with MRF in metastatic bone disease, muscle, fat and bone marrow, compares them with values obtained in volunteers using gold-standard imaging and MRF and demonstrates increased T1 and T2 in lesions compared with normal marrow and values in volunteers.

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