Apparent diffusion coefficient (ADC) can be a useful marker to track the degeneration of the knee cartilage during the early stage of osteoarthritis. We recently observed that the estimated ADC values change depending on the adopted b-values used in a DW-EPI sequence. We tested our hypothesis about this b-value dependence of ADC with in-vivo knee scans of 7 healthy subjects. Our statistical test result shows that the ADC estimated with the smaller b-values (0~150 s/mm2) is significantly higher than the ADC estimated with the larger b-values (0~800 s/mm2), suggesting the possibility of multi-component diffusion in the knee cartilage.
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