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Abstract #1387

The b-value dependence of apparent diffusion coefficient (ADC) values in the knee cartilage

Daehyun Yoon1, Sanghee Choi2, Bragi Sveinsson3, and Brain Hargreaves1

1Radiology, Stanford University, Stanford, CA, United States, 2Radiology, Sungkyunkwan University, Suwon, Korea, Republic of, 3Radiology, Harvard Medical School, Charlestown, MA, United States

Apparent diffusion coefficient (ADC) can be a useful marker to track the degeneration of the knee cartilage during the early stage of osteoarthritis. We recently observed that the estimated ADC values change depending on the adopted b-values used in a DW-EPI sequence. We tested our hypothesis about this b-value dependence of ADC with in-vivo knee scans of 7 healthy subjects. Our statistical test result shows that the ADC estimated with the smaller b-values (0~150 s/mm2) is significantly higher than the ADC estimated with the larger b-values (0~800 s/mm2), suggesting the possibility of multi-component diffusion in the knee cartilage.

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