Meeting Banner
Abstract #1415

MRI Off-Resonance Analysis Correlates with Histology Necrosis Observations in Failed Total Hip Arthroplasty

Kevin Koch1, Juan Liu2, Matthew F Koff3, and Hollis Potter3

1Radiology, Medical College of Wisconsin, Milwaukee, WI, United States, 2Biomedical Engineering, Marquette University and Medical College of Wisconsin, Milwaukee, WI, United States, 3Magnetic Resonance Imaging, Hospital for Special Surgery, New York, NY, United States

This study presents the analysis of 78 total hip arthroplasty revision subjects that underwent advanced MRI off-resonance analysis and optical histology necrosis grading of tissue biopsies. The off-resonance analysis, which leverages multi-spectral MRI methods, sought to quantify metal particle deposition in tissues or “metallosis”. Direct measurements of off-resonance signatures correlated strongly with histology necrosis grade (p < 0.013). The results of this study provide encouragement that quantitative MRI may be useful as a non-invasive biomarker of tissue destruction in symptomatic total hip arthroplasty.

This abstract and the presentation materials are available to members only; a login is required.

Join Here