Abstract #1415

MRI Off-Resonance Analysis Correlates with Histology Necrosis Observations in Failed Total Hip Arthroplasty

Kevin Koch¹, Juan Liu², Matthew F Koff³, and Hollis Potter³

¹Radiology, Medical College of Wisconsin, Milwaukee, WI, United States, ²Biomedical Engineering, Marquette University and Medical College of Wisconsin, Milwaukee, WI, United States, ³Magnetic Resonance Imaging, Hospital for Special Surgery, New York, NY, United States

This study presents the analysis of 78 total hip arthroplasty revision subjects that underwent advanced MRI off-resonance analysis and optical histology necrosis grading of tissue biopsies. The off-resonance analysis, which leverages multi-spectral MRI methods, sought to quantify metal particle deposition in tissues or “metallosis”. Direct measurements of off-resonance signatures correlated strongly with histology necrosis grade (p < 0.013). The results of this study provide encouragement that quantitative MRI may be useful as a non-invasive biomarker of tissue destruction in symptomatic total hip arthroplasty.

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