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Abstract #1426

Visualization and quantification of epiphyseal cartilage vasculature using quantitative susceptibility maps of pediatric knee specimens

Kai D. Ludwig1,2, John Strupp1,2, Casey P. Johnson1,2, Stefan Zbyn1,2, Mikko J. Nissi1,2,3, Ferenc Tóth4, Kevin Shea5, Cathy S. Carlson6, and Jutta M. Ellermann1,2

1Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, United States, 2Radiology, University of Minnesota, Minneapolis, MN, United States, 3Applied Physics, University of Eastern Finland, Kuopio, Finland, 4Veterinary Population Medicine, University of Minnesota, St. Paul, MN, United States, 5Orthopaedic Surgery, Stanford University, Stanford, CA, United States, 6Veterinary Clinical Sciences, University of Minnesota, St. Paul, MN, United States

Visualization of the vasculature within the epiphyseal cartilage of the distal femur of the skeletally immature knee joint is possible with susceptibility-weighted MRI. A post-processing pipeline is described to segment and quantify the vascular density within two distinct vascular beds of the distal femoral epiphyseal cartilage using quantitative susceptibility maps. The described post-processing may allow identification of vascular abnormalities at early stages of development and also may improve assessment of therapeutic interventions.

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