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Abstract #1442

Neurological and Neuropsychological Status of Patients with Numerous Applications of Gadolinium-Based Contrast Agents. Follow up of 14-16 Years

Josef Vymazal1, Lenka Kramska2, Hana Brozova3, and Aaron M Rulseh1

1Radiology, Na Homolce Hospital, Prague, Czech Republic, 2Neurology, Na Homolce Hospital, Prague, Czech Republic, 3Neurology, Charles University in Prague, Prague, Czech Republic

Gadolinium deposition in the brain following gadolinium-based contrast agents (GBCA) application has become an important safety concern, however investigations into the effect of gadolinium deposition remain limited. We performed neurological and neuropsychological evaluation in four patients that received very high cumulative doses of linear and macrocyclic GBCAs (mean 728.25 ml, range 562–915 ml) over a range of 14–16 years. Although increased T1 signal was observed in the globus pallidus and dentate nuclei of all patients, the neurological status did not change. No signs of extrapyramidal symptomatology were detected, nor did neuropsychological testing reveal any relevant impairment implicating involvement.

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