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Abstract #1492

Minimally invasive implantable NMR microcoil for in vivo MRS and MRI in submicroliter volumes

Yannick Crémillieux1, Noël Pinaud1, Benadjem Felouah1, Vi Thi Thuy Pham1, and Alan Wong2

1Institut des Sciences Moléculaires, CNRS, Université de Bordeaux, Bordeaux, France, 2NIMBE, CEA Saclay, Gif-sur-Yvette, France

Due to sensitivity and invasiveness issues, the use of implanted NMR microprobes remains a poorly explored field of research, with no emerging or significant biomedical applications. In this study, we report the realization, characterization and applicaiton of an innovative design for implantable microprobe allowing a drastic minimization of the probe invasiveness. The results obtained in vitro and in vivo demonstrate the potential of this microprobe architecture for MRS and MRI investigation of organs and tissues in submicroliter volumes.

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