T2-weighted MRI, an integrated part of multi-parametric MRI for prostate cancer diagnostics, is indispensable for qualitative evaluation of prostate anomalies. For quantitative assessment, however, normalization is necessary for comparison within and between patients. In this study, we developed and validated a fully automated object recognition method for multi-reference tissue normalization. The performance of the method was superior to existing fully automated normalization strategies, and the resulting pseudo T2 values were close to true T2 values from literature. The developed multi-reference tissue normalization method may thus improve the reproducibility and diagnostic performance of T2-weighted image features in future quantitative applications.
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