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Abstract #1616

Optimized 3D Variable Flip Angle Fast Spin Echo: Simulating Different Prostate Tissue Types to Improve Contrast for Prostate Cancer Detection

Steven M Shea1,2

1Stritch School of Medicine, Loyola University Chicago, Maywood, IL, United States, 2Radiology, Loyola University Medical Center, Maywood, IL, United States

MRI of the prostate has become a crucial component of prostate cancer diagnosis. Most clinical sites use 2D FSE for T2 imaging. However, drawbacks exist and some institutions have moved to 3D using FSE-VFL. While groups have presented clinical results using FSE-VFL, none have published detailed investigations of different flip angle trajectories and parameter choices for maximizing lesion contrast in prostate cancer imaging. Flip angle trajectories were simulated for 3D FSE-VFL using T1 and T2 appropriate for prostate and then tested in a phantom. Overall, signal simulations proved useful for analyzing different parameters and flip angle trajectories for T2-weighted sequences.

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