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Abstract #1635

Hyperpolarized 129Xe dissolved-phase MR detects physiological changes in human lungs after low-dose inhaled lipopolysaccharide challenge

Agilo L Kern1,2, Filip Klimes1,2, Andreas Voskrebenzev1,2, Marcel Gutberlet1,2, Heike Biller2,3, Julius Renne1,2, Olaf Holz2,3, Frank Wacker1,2, Jens M Hohlfeld2,3,4, and Jens Vogel-Claussen1,2

1Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, 2Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany, 3Department of Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany, 4Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany

Low-dose inhalation of lipopolysaccharide (LPS) provides a disease model in humans for development of anti-inflammatory drugs but sensitive methods for assessment of the inflammatory response to LPS are lacking. The feasibility of hyperpolarized 129Xe dissolved-phase imaging and chemical shift saturation recovery (CSSR) was investigated in this setting. The ratio of 129Xe in red blood cells and in tissue/plasma was found to decrease and the capillary transit time derived from CSSR was found to increase after LPS inhalation. These effects are attributed to pulmonary edema and vasodilation. In conclusion, hyperpolarized 129Xe MR is sensitive even for low-dose LPS challenges in humans.

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