Abstract #1647

MRI-based R2* Mapping in Patients with Suspected or Known Iron Overload

An Lesage¹, Philippe Paquin¹, Jack W Luo², Milena Cerny^1,3, Anne Shu-Lei Chin¹, Damien Olivié¹, Guillaume Gilbert^1,4, Denis Soulières⁵, and An Tang^1,3

¹Department of Radiology, Centre hospitalier de l'Université de Montréal, Montréal, QC, Canada, ²McGill University, Montréal, SK, Canada, ³Centre de recherche du Centre hospitalier de l'Université de Montréal, Montréal, QC, Canada, ⁴MR Clinical Science, Philips Healthcare Canada, Markham, ON, Canada, ⁵Department of Hematology-oncology, Centre hospitalier de l'Université de Montréal, Montréal, QC, Canada

The purpose of this study is to analyze the cross-sectional relationships of MRI-based R2* relaxometry values in organs across patients with various types of iron overload. Further analyses were conducted to analyze R2* values in organs according to the treatment regimen of patients (transfusion, phlebotomy, and chelation therapy). This retrospective, cross-sectional study includes 82 adult patients with known or suspected iron overload due to primary and secondary hemochromatosis. Results revealed differences between degree of iron overload in organs according to the underlying pathology and treatment regimens.

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