Abstract #1674

A new MR-based Perianal Crohn’s disease activity score: Multicentre study

Ali Alyami^1,2,3, Caroline Hoad^1,3, Konstantinos Argyriou⁴, White Jonathan⁴, Uday Bannur⁵, Khalid Latief⁵, Christopher Clarke⁵, Phillip Lung⁶, Penny Gowland³, and Gordon Moran^1,4

¹Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham, United Kingdom, ²Faculty of Applied Medical Sciences, Diagnostic Radiology, Jazan University, Jazan, Saudi Arabia, ³Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ⁴NIHR Nottingham Biomedical Research Centre at Nottingham University Hospitals NHS Trust and University of Nottingham, University of Nottingham, Nottingham, United Kingdom, ⁵Radiology, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom, ⁶Radiology, St Mark's Hospital and London North West Healthcare NHS Trust, London, United Kingdom

Perianal Crohn’s disease (pCD) is a potential complication in CD. Absence of reliable disease measures makes disease monitoring unreliable. MRI is an effective imaging method for the evaluation of patients with pCD. Quantitative MRI sequences, such as diffusion-weighted image (DWI), and magnetization transfer (MT) offer opportunities to improve diagnostic capability. The aim of this study was to measure disease activity within a pCD patient cohort using quantitative MRI sequences (DWI and MT), at different field strengths, before and after biological therapy. The study is ongoing with patients presenting with a range of clinical and inflammatory markers of disease activity.

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