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Abstract #1695

Comparison of Diagnostic Values of Mono-exponential, Bi-exponential, and Stretched Exponential Diffusion-weighted Magnetic Resonance Imaging in Differentiating Benign and Malignant Hepatic Lesions

Yoshifumi Noda1, Satoshi Goshima1, Kimihiro Kajta1, Yuta Akamine2, Masatoshi Honda2, Tomoyuki Okuaki2, Hiroshi Kadohara2, Nobuyuki Kawai1, Hiroshi Kawada1, Yukichi Tanahashi1, and Masayuki Matsuo1

1Radiology, Gifu University, Gifu, Japan, 2Philips Healthcare, Tokyo, Japan

Intravoxel incoherent motion, a bi-exponential model of diffusion-weighted imaging with multiple b values, can represent pure molecular diffusion and perfusion, and be used in characterizing focal hepatic lesions. Recently, stretched exponential model has been used in glioblastoma and prostate cancer. In this study, we evaluated the feasibility of stretched exponential model for differentiating benign and malignant hepatic lesions. Our results showed that DDC value from a stretched exponential model was the highest diagnostic potential, so it could be a quantitative imaging biomarker for differentiating benign and malignant hepatic lesions.

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