Meeting Banner
Abstract #1708

A Two-Center Analysis of Hyperpolarized 129Xe Lung MRI in Stable Pediatric Cystic Fibrosis: Comparison of Image Analysis Approaches

Marcus J. Couch1,2, Robert Thomen3, Felix Ratjen1,4, Jason Woods5, and Giles Santyr1,2

1Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada, 2Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3School of Medicine, University of Missouri, Columbia, MO, United States, 4Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada, 5Center for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States

The ventilation defect percent (VDP), measured from hyperpolarized 129Xe MRI, is sensitive to functional changes in early cystic fibrosis (CF) lung disease; however, there is no consensus on which VDP calculation method is most appropriate for future multi-center clinical trials in CF. This study compared VDP analysis methods in hyperpolarized 129Xe datasets acquired in stable pediatric CF subjects at two institutions. In a combined dataset, a comparison of k-means, mean-anchored linear binning, and 99th percentile-anchored linear binning demonstrated that all three methods provide a good characterization of the disease, but mean-anchored linear binning provided the strongest correlation to pulmonary function tests.

This abstract and the presentation materials are available to members only; a login is required.

Join Here