Abstract #1732

Three-dimensional MR Elastography (MRE) can replace 2D MRE in staging liver fibrosis: Noninferiority test of the area under the ROC curve and comparison of image quality.

Hao Yang¹, Hezhi Lu², Yong Liu³, Sichi Kuang¹, Bingjun He¹, Kevin J Glaser⁴, Meng Yin⁴, Sudhakar K Venkatesh⁴, Bing Wu⁵, Richard L Ehman⁴, and Jin Wang¹

¹Department of Radiology, The third affiliated hospital of Sun Yat-sen University, Guangzhou, China, ²South China Normal University, Guangzhou, China, ³Department of Pathology, The third affiliated hospital of Sun Yat-sen University, Guangzhou, China, ⁴Department of Radiology, Mayo Clinic, Rochester, MN, United States, ⁵MR Research China, GE Healthcare, Beijing, China

2D MR elastography (MRE) has been shown to be the most accurate noninvasive technique for the detection and staging of liver fibrosis. Tissue stiffness quantification based on 3D MRE is theoretically more accurate while having comparable diagnostic accuracy for staging fibrosis. Our results showed that the diagnostic performance of 3D MRE is not inferior to 2D MRE in assessing liver fibrosis by using a noninferiority test of the area under the ROC curve based on the restricted maximum likelihood (REML) method. Moreover, 3D MRE had better image quality and has the potential to replace 2D MRE in clinical applications.

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