Abstract #1734

Liver fibrosis detection and staging in rats: a comparative study of T1 relaxation time in the rotating frame block sequence and adiabatic sequence.

Da Shi¹, Xianyue Quan¹, Yingjie Mei², Shisi Li³, and Genwen Hu⁴

¹Radiology department, Zhujiang hospital of southern medical university, Guangzhou, China, ²MR clinical science, Philips Healthcare, Guangzhou, China, ³Radiology department, Guangzhou, China, ⁴Radiology department, Shenzhen people's hospital, Shenzhen, China

Objective: To compare diagnostic performances on staging liver fibrosis of T1 relaxation time in the rotating frame block sequence and adiabatic sequence. Materials and Methods: 65 healthy Sprague Dawley (SD) rats were randomly divided into model and black groups. Block T1ρ and adiabatic T1ρ were performed on the rats with a 3.0-T clinical scanner. Results: T1ρ values were significantly different among stages (P <0.05), except for stages S1 and S2 with block T1ρ. AUC for block T1ρ values were 0.989, 0.924, 0.932 and 0.923, respectively. AUC for Adiabatic T1ρ values were 0.992，0.948，0.967 and 0.963, respectively. Conclusions: Adiabatic T1ρvalues had higher diagnositic performances on staging liver fibrosis in rats.

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