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Abstract #1745

Gadoxetic acid-enhanced perfusion quantification in the liver and spleen in portal hypertension

Stefanie Hectors1,2, Octavia Bane1,2, Paul Kennedy1,2, Scott Friedman3, Thomas Schiano3, Maria Isabel Fiel4, Swan Thung4, Aaron Fischman5, and Bachir Taouli1,2

1Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 3Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 4Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 5Department of Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States

The goal of our study was to assess the potential value of perfusion quantification using DCE-MRI with gadoxetic acid in the liver and spleen for noninvasive assessment of portal hypertension (PH). We found that the liver uptake fraction was significantly negatively correlated with hepatic venous pressure gradient measurements. We conclude that liver perfusion quantification is promising for noninvasive assessment of PH. After validation of these findings in a larger cohort of patients, DCE-MRI may potentially decrease the need of invasive portal pressure measurements.

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