Abstract #1759

A new calibration between R2* and Liver Iron Concentration derived from 167 clinical cases

Gregory Colin Brown^1,2, Gary J Cowin¹, and Graham J Galloway^1,3

¹Centre for Advanced Imaging, University of Queensland, St Lucia, Qld., Australia, ²School of Health Sciences, University of South Australia, Adelaide, SA, Australia, ³Translational Research Institute, Woolangabba Qld., Australia

The commonly used equation to determine Liver iron concentration (LIC) from R2* was developed from a very small cohort (n=23) and an acquisition approach significantly different to that currently used in clinic. Three subsequent calibrations used progressively larger moderate (n=43-88) to derive divergent results. This study measured liver R2* from 835 gradient echo relaxometry acquisitions in 167 clinical examinations. Correlation between R2* and reference LIC measurement was evaluated for first to third order polynomials. A linear equation provided the best fit, delivering a new calibration equation that differs significantly from earlier work.

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