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Abstract #1759

A new calibration between R2* and Liver Iron Concentration derived from 167 clinical cases

Gregory Colin Brown1,2, Gary J Cowin1, and Graham J Galloway1,3

1Centre for Advanced Imaging, University of Queensland, St Lucia, Qld., Australia, 2School of Health Sciences, University of South Australia, Adelaide, SA, Australia, 3Translational Research Institute, Woolangabba Qld., Australia

The commonly used equation to determine Liver iron concentration (LIC) from R2* was developed from a very small cohort (n=23) and an acquisition approach significantly different to that currently used in clinic. Three subsequent calibrations used progressively larger moderate (n=43-88) to derive divergent results. This study measured liver R2* from 835 gradient echo relaxometry acquisitions in 167 clinical examinations. Correlation between R2* and reference LIC measurement was evaluated for first to third order polynomials. A linear equation provided the best fit, delivering a new calibration equation that differs significantly from earlier work.

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