Abstract #1762

MRI Relaxometry in a Rat Model of Nonalcoholic Steatohepatitis (NASH)

Iris Y. Zhou¹, Nicholas Rotile¹, Veronica Clavijo Jordan¹, Gunisha Arora², Smitha Krishnan², Hannah Slattery¹, Noah Warner¹, Christian T. Farrar¹, Bryan C. Fuchs², and Peter Caravan¹

¹Athinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging (i3), Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, ²Division of Surgical Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States

Nonalcoholic steatohepatitis (NASH), characterized by the presence of steatosis, inflammation and fibrosis, has a high prevalence and is associated with poor outcomes. While liver biopsy is the gold standard for assessment of fibrosis, it is invasive with potential complications. Recently, liver T1 measurement without intravenous contrast has been proposed to stage liver fibrosis. Here, we evaluated T1 mapping for monitoring disease progression and treatment response in a choline-deficient high-fat diet rat model of NASH. Instead of correlating with fibrosis, we found a strong correlation of T1 with histologically determined liver fat fraction but not with histological and biochemical measures of fibrosis.

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