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Abstract #1770

Quantitative Measurement of Serial Contrast Agent Distribution between Liver and Blood in Patients with Chronic Liver Disease using T1 mapping

Puneet Sharma1

1Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, United States

This study investigates the post-contrast time sensitivity of liver-to-blood partition coefficient. In vivo change in liver-to-blood contrast distribution was calculated at 3 time-points following contrast administration using a fast inversion-recovery Look-Locker T1 mapping approach. While measurement and exam time variation did not reveal a consistent equilibrium time threshold, results show that contrast distribution becomes increasingly different between chronic and non-chronic liver disease groups at least 5 minutes post-contrast, allowing possible measurement of liver extracellular volume fraction.

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