This study investigates the post-contrast time sensitivity of liver-to-blood partition coefficient. In vivo change in liver-to-blood contrast distribution was calculated at 3 time-points following contrast administration using a fast inversion-recovery Look-Locker T1 mapping approach. While measurement and exam time variation did not reveal a consistent equilibrium time threshold, results show that contrast distribution becomes increasingly different between chronic and non-chronic liver disease groups at least 5 minutes post-contrast, allowing possible measurement of liver extracellular volume fraction.
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