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Abstract #1775

Clinical, technical, and biochemical predictors of adequate hepatobiliary phase enhancement on Gadobenate-Dimeglumine-enhanced MRI of the liver in patients with chronic liver disease and HCC

Jingbiao Chen1, Sichi Kuang1, Yao Zhang1, Hao Yang1, Ying Deng1, Bingjun He1, Kathryn Fowler2, Claude B. Sirlin2, and Jin Wang1

1Department of Radiology, The third affiliated hospital of Sun Yat-sen University, guangzhou, China, 2Department of Radiology, University of California at San Diego, La Jolla, CA, United States

Liver dysfunction impairs the uptake of gadobenate dimeglumine by liver parenchyma, which reduces hepatocellular carcinoma (HCC) conspicuity on hepatobiliary phase (HBP) images. Although the effect of Child-Pugh class and some biologic factors have been investigated, there is a paucity of data on other plausible predictors of HBP adequacy. Here we show that elevated albumin level, prolonged HBP delay time, and absence of liver cirrhosis predict HBP adequacy on gadobenate-MRI in patients with chronic liver disease and HCC. In the subset of patients with cirrhosis and HCC, adequate HBP was associated with elevated serum creatinine level and prolonged HBP delay time.

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