Abstract #1777

A Quantitative MRI Phantom to Mimic the Simultaneous Presence of Fat, Iron, and Fibrosis

Ruiyang Zhao^1,2, Gavin Hamilton³, Jean H. Brittain^1,4, Scott B. Reeder^1,2,4,5,6,7, and Diego Hernando^1,2,4

¹Radiology, University of Wisconsin-Madison, Madison, WI, United States, ²Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ³Radiology, University of California, San Diego, San Diego, CA, United States, ⁴Calimetrix LLC, Madison, WI, United States, ⁵Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁶Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁷Medicine, University of Wisconsin-Madison, Madison, WI, United States

Fat, iron and fibrosis are important features of liver disease that commonly coexist. Emerging quantitative MRI biomarkers including proton density fat fraction (PDFF), R2*/R2 and T1 enable quantification of fat, iron, and fibrosis, respectively, and require quantitative MR phantoms for validation and quality assurance. Although current phantoms enable separate adjustment of PDFF, R2*/R2 or T1, there is an unmet need for phantoms that accurately mimic MRI signals in the presence of simultaneous fat, iron and fibrosis by jointly controlling PDFF, R2*/R2 and T1. In this work, we develop and validate a novel phantom that jointly controls PDFF, R2*/R2 and T1.

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