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Abstract #1781

Stretched exponential diffusion-weighted imaging model in quantitative diagnosis of nonalcoholic fatty liver disease : a rabbit model study

Chang li1,2, Xianfu luo2, Weiqiang Dou3, Yun Peng1, Jingtao wu2, and Jing Ye2

1XiangYa school of medicine, Central South University, Changsha, China, 2Clinical Medical School of Yangzhou University, Northern Jiangsu People’s Hospital, Yangzhou, China, 3GE Healthcare,MR Research China, beijing, China

We aimed to investigate if a stretched exponential diffusion weighted imaging model (SEM) can be applied to assess nonalcoholic liver disease (NAFLD) disease by providing distributed-diffusion-coefficient (DDC) and α separately evaluating mean intravoxel diffusion rate and diffusion heterogeneity. The SEM model was then applied to analyze NAFLD in a rabbit model and compared with a mono-exponential (ME) model. While DDC from the SEM model showed comparable values with apparent-diffusion-coefficient (ADC) estimated in the ME model, alpha indicated more robust performance in the diagnosis of nonalcoholic steatohepatitis (NASH). Therefore, SEM model showed a great potential in early diagnosis of NASH.

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