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Abstract #1785

High-fat stimulation in healthy subjects: Longitudinal monitoring of bile acid and diffusivity changes in the gallbladder by MRS and MRI

Peter Vermathen1, Dino Kroell2, Philipp Nett2, Guido Stirnimann2, and Reiner Wiest2

1DBMR & DIPR, University of Bern, Bern, Switzerland, 2Department of Visceral Surgery and Medicine, University Inselspital, Bern, Switzerland

Bile exerts multiple functions in the liver and gut and is a key player in disease processes. In this pilot study we implemented a standardized stimulation test with high-fat diet in lean physically fit individuals and performed MRS and MRI measurements longitudinally to monitor bile acid composition and diffusivity changes in the gallbladder, with the long term aim to determine a specific bile-acid-microbiota “signature”. Strongly increased bile acid and lipid resonances and reduced diffusivity after lipid ingestion were determined as well as reversal to base values within 24h, demonstrating the feasibility and potential of the method.

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