Liver DWI is complicated by multiple challenges, including the relatively short T2 of liver tissue and the motion sensitivity of diffusion encoding sequences. In this study, a novel approach for the design of diffusion weighting waveforms, termed M1-Optimized Diffusion Imaging (MODI), is proposed for motion-robust, blood-suppressed liver DWI. MODI includes an echo-time optimized motion-robust diffusion weighting gradient waveform design, with a moderate non-zero first-moment (M1≠0) value to enable blood signal suppression. This work describes the proposed MODI method, and evaluates its effectiveness in healthy volunteers as well as in patients.
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