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Abstract #1792

Motion-Robust and Blood-Suppressed M1-Optimized Diffusion MR Imaging of the Liver

Yuxin Zhang1,2, Óscar Peña-Nogales3, James H Holmes2, and Diego Hernando1,2

1Medical Physics, University of Wisconsin Madison, madison, WI, United States, 2Radiology, University of Wisconsin Madison, madison, WI, United States, 3Laboratorio de Procesado de Imagen, Universidad de Valladolid, Valladolid, Spain

Liver DWI is complicated by multiple challenges, including the relatively short T2 of liver tissue and the motion sensitivity of diffusion encoding sequences. In this study, a novel approach for the design of diffusion weighting waveforms, termed M1-Optimized Diffusion Imaging (MODI), is proposed for motion-robust, blood-suppressed liver DWI. MODI includes an echo-time optimized motion-robust diffusion weighting gradient waveform design, with a moderate non-zero first-moment (M1≠0) value to enable blood signal suppression. This work describes the proposed MODI method, and evaluates its effectiveness in healthy volunteers as well as in patients.

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