Abstract #1807

Dynamic contrast-enhanced magnetic resonance imaging parameters for characterizing rectal cancer with different KRAS status

Hongliang Sun¹ and Yanyan Xu^1,2

¹Radiology, China-Japan Friendship Hospital, Beijing, China, ²Graduate school of medical science, University of the Ryukyus, Okinawa, Japan

DCE-MRI can noninvasively reveal the presence and the permeability of micro-capillaries by the kinetic analysis of the contrast concentration¹. It has been used in the studies for diagnosis, characterization of predictive prognostic factors, monitoring of treatment response, and evaluation of the efficacy of novel treatment developments^2-3. KRAS mutation has been well known as predictive markers of resistance to epidermal growth factor receptor-targeted antibodies, may be useful as molecular markers for the clinical prognosis of CRCs⁴. However, There a are few data about whether the DCE-MRI parameters would behave different characteristics in rectal cancers with different KRAS status.

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