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Abstract #1807

Dynamic contrast-enhanced magnetic resonance imaging parameters for characterizing rectal cancer with different KRAS status

Hongliang Sun1 and Yanyan Xu1,2

1Radiology, China-Japan Friendship Hospital, Beijing, China, 2Graduate school of medical science, University of the Ryukyus, Okinawa, Japan

DCE-MRI can noninvasively reveal the presence and the permeability of micro-capillaries by the kinetic analysis of the contrast concentration1. It has been used in the studies for diagnosis, characterization of predictive prognostic factors, monitoring of treatment response, and evaluation of the efficacy of novel treatment developments2-3. KRAS mutation has been well known as predictive markers of resistance to epidermal growth factor receptor-targeted antibodies, may be useful as molecular markers for the clinical prognosis of CRCs4. However, There a are few data about whether the DCE-MRI parameters would behave different characteristics in rectal cancers with different KRAS status.

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