Abstract #1810

Whole-Tumor Histogram Analysis of Diffusion Kurtosis Imaging as A Predictive Biomarker of Tumor Response in Locally Advanced Rectal Cancer Treated with Neoadjuvant Chemoradiation

Sun Yiqun¹, Tong Tong¹, Fu Caixia², Yan Xu³, Peng Weijun¹, and Gu Yajia¹

¹Fudan University Shanghai Cancer Center, Shanghai, China, ²MR Application Development, Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, ³MR Collaboration NE Asia, Siemens Healthcare, Shanghai, China

We investigate the potential of thewhole-tumor histogram of conventional DWI and DKI derived parameters to predict the tumor response to neoadjuvant chemoradiation therapy in locally advanced rectal cancer. Our study demonstrated that whole-tumor histogram analysis of DKI derived parameter maps has potential value to predict tumor response.

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