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Abstract #1810

Whole-Tumor Histogram Analysis of Diffusion Kurtosis Imaging as A Predictive Biomarker of Tumor Response in Locally Advanced Rectal Cancer Treated with Neoadjuvant Chemoradiation

Sun Yiqun1, Tong Tong1, Fu Caixia2, Yan Xu3, Peng Weijun1, and Gu Yajia1

1Fudan University Shanghai Cancer Center, Shanghai, China, 2MR Application Development, Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, 3MR Collaboration NE Asia, Siemens Healthcare, Shanghai, China

We investigate the potential of thewhole-tumor histogram of conventional DWI and DKI derived parameters to predict the tumor response to neoadjuvant chemoradiation therapy in locally advanced rectal cancer. Our study demonstrated that whole-tumor histogram analysis of DKI derived parameter maps has potential value to predict tumor response.

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