This study concentrated on the correlation between radiomics parameters and the tumor-stromal ratio. We identified several radiomics parameters that may reflect the content of tumor-stroma. After constructed a radiomics signature based on the tumor-stromal ratio and furtherly applied the signature into the LARC patients with neoadjuvant chemoradiotherapy, we found that the TSR-conducted radiomics signature was significantly correlated with pCR and non-pCR. The radiomics signature may serve as a non-invasive imaging biomarker for pretreatment prediction of treatment response.
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