Abstract #1816

Quantitative intravoxel incoherent motion (IVIM) parameters derived from whole-tumor volume for predicting and assessing pathological complete response to neoadjuvant chemotherapy in locally advanced rectal cancer

Qiaoyu Xu^1,2, Yanyan Xu¹, Queenie Chan³, and Hongliang Sun¹

¹Radiology, China-Japan Friendship Hospital, Beijing, China, ²Radiology, Beijing Chao-yang Hospital, Beijing, China, ³Research center, Philips Healthcare, HongKong, China

Neoadjuvant chemotherapy has been widely applied in treating locally advanced rectal cancer (LARC) for effectively decreasing the local recurrence after total mesorectal excision(TME)¹. Some of patients may achieve a pathological complete response (pCR). The pCR rate of LARC has been reported to be 10%–30%^2-3. The imaging technique of intravoxel incoherent motion(IVIM) model, which could estimate tissue perfusion and diffusion components individually using multi-b-values was introduced to evaluate tumor treatment response4. In this study, we found that IVIM-dreived D values is a promising tool in predicting pCR status before therapy.

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