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Abstract #1844

Accuracy of IMPROD biparametric pre-biopsy MRI for prostate cancer detection in correlation with whole mount prostatectomy sections: implications for focal therapy (IMPROD trial, #opensourcetrial)

Harri Merisaari1, Pekka Taimen2, Otto Ettala2, Peter Boström2, Ileana Montoya Perez1, Janne Verho1, Aida Kiviniemi1, Kari Syvänen2, Esa Kähkönen2, Tapio Pahikkala1, Jani Saunavaara2, Hannu Aronen1, and Ivan Jambor1,3

1University of Turku, Turku, Finland, 2Turku University Hospital, Turku, Finland, 3Icahn School of Medicine at Mount Sinai, New York, NY, United States

In this prospective single institutional trial(NCT01864135), we evaluated the accuracy of a unique prostate MRI acquisition and reporting protocol, IMPROD biparametric MRI, in men with a clinical suspicion of prostate cancer who were subsequently diagnosed with prostate cancer and underwent prostatectomy. IMPROD biparametric MRI correctly detected 75% (75/99) of prostate cancer lesions with diameter ≥5 mm or any Gleason grade 4, and only two of the missed prostate cancer lesions had Gleason score >3+4. However, only a limited accuracy on isotropic voxel level was achieved potentially limiting focal therapy planning. All data are freely are available at the following address:

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