Abstract #1848

Probing Structure of Normal and Malignant Prostate Tissue before and after Radiation Therapy with Luminal Water Fraction and Diffusion-Weighted MRI

Dominic Carlin¹, Matthew Orton¹, David J Collins^1,2, and Nandita M deSouza^1,2

¹Cancer Research UK Imaging Centre, The Institute of Cancer Research, Sutton, United Kingdom, ²MRI Unit, The Royal Marsden Hospital NHS Foundation Trust, Sutton, United Kingdom

Luminal Water Fraction (LWF) is higher in peripheral than transitional zone of the untreated prostate; in comparison, it is significantly reduced in tumors. LWF is correlated with ADC in untreated non-malignant prostate. LWF is not correlated with ADC in tumors or in post irradiated prostate indicating that the morphological factors affecting LWF and ADC in these tissues are independent.

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