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Abstract #1853

A meta-analysis comparing the diagnostic performance of Diffusion-Weighted Imaging (DWI), Diffusion Tensor Imaging (DTI), and Intra-voxel Incoherent Motion (IVIM) in breast cancer

Gabrielle C Baxter1, Martin J Graves2, Fiona J Gilbert1, and Andrew J Patterson2

1Department of Radiology, University of Cambridge, Cambridge, United Kingdom, 2Department of Radiology, Addenbrooke's Hospital, Cambridge, United Kingdom

The performance of parameters from diffusion-weighted imaging (DWI), diffusion tensor imaging (DTI) and intra-voxel incoherent motion (IVIM) in the differential diagnosis of malignant and benign breast lesions were compared through a meta-analysis. 73 eligible studies were included and pooled estimates of sensitivity, specificity and area under the curve were obtained for each of the model parameters. The highest performing parameters for DTI and IVIM were the prime diffusion coefficient (λ1) and the tissue diffusivity (D), respectively. DWI, DTI and IVIM are diagnostically comparable, though there is a lack of standardisation in methodology for each technique.

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