Abstract #1856

Change in breast cancer functional tumor volume and contralateral background parenchymal enhancement is associated with pathological complete response to neoadjuvant therapy

Fredrik Strand^1,2, Vignesh Arasu¹, Wen Li¹, Roy Harnish¹, Ella Jones¹, David C. Newitt¹, Bonnie N. Joe¹, Laura Esserman³, and Nola Hylton¹

¹Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ²Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden, ³Department of Surgery, University of California San Francisco, San Francisco, CA, United States

For women with locally advanced breast cancer, we have examined the change in quantitative measures of MRI tumor volume and background parenchymal enhancement between pre-treatment and after 12 weeks of treatment. In a multivariate model, we found that a larger decrease in MRI tumor volume or in quantitative BPE was associated with higher probability of pathological complete response.

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