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Abstract #1860

Changes in breast tumor blood flow measured by dynamic contrast-enhanced MRI after one cycle of neoadjuvant chemotherapy

William Stevens1, Leonidas Georgiou1, Andrew M. Hanby1, Daniel J. Wilson2, Nisha Sharma2, Timothy J. Perren1, David Dodwell2, Barbara J. Dall2, and David L. Buckley1

1University of Leeds, Leeds, United Kingdom, 2Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

Early assessment of response to neoadjuvant chemotherapy (NACT) in breast cancer is important and it has been suggested that functional changes, such as tumor blood flow (TBF), may precede size changes. We measured TBF using dynamic contrast-enhanced MRI in 40 patients before and after one cycle of NACT and compared these measures to pathological response. There was no correlation between change in TBF and pathological response in the full sample. However, several tumors shrank after one cycle of NACT; if these were removed then change in TBF in tumors that didn’t shrink correlated well with pathological response

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