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Abstract #1865

Diffusion kurtosis imaging and intravoxel incoherent motion analysis in comparison to a combination of multi-level diffusion coefficients in MR mammography of suspicious breast lesions

Anna Mlynarska-Bujny1,2, Sebastian Bickelhaupt2, Franziska König2, Frederik Bernd Laun3, Wolfgang Lederer4, Heidi Daniel5, Stefan Delorme2, Heinz-Peter Schlemmer2, and Tristan Anselm Kuder1

1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 3Institute of Radiology, University Hospital Erlangen, Erlangen, Germany, 4Radiological Practice at the ATOS Clinic Heidelberg, Heidelberg, Germany, 5Radiology Center Mannheim (RZM), Mannheim, Germany

Diffusion-weighted imaging (DWI) is increasingly used in MR mammography for assessing malignancy of breast lesions. In particular, quantitative analysis of DWI data acquired with several b-values is gaining importance. Common data evaluation approaches include intravoxel incoherence motion (IVIM) and kurtosis imaging. The aim of this work was to evaluate the performance of kurtosis and IVIM based parameters in comparison to an approach combining several conventional diffusion coefficients measured with different b-values. The dataset comprised 198 examinations of patients with suspicious mammography findings. The simple approach using several ADCs showed a similar performance as the combination of kurtosis and IVIM.

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